From 2020 to 2030, CIO significance will depend on digital transformation success. But there's so much uncertainty and no one knows exactly what will happen next. Fear, complacency and apathy create natural reactions: wait and hold. Three megatrends provide both opportunities and threats to CIO and organizational success: climate change, China and Centennials. CIOs can turn uncertainty into opportunity by mastering these megatrends with emerging technologies.