The events of the last two years have imposed the biggest ever uncontrolled experiment on the human mind, having effects in ways and to extents that it is hard to predict. The human brain becomes highly personalized after birth by the development of unique configurations of connections between the brain cells that characterize its subsequent growth, personalizing it into a highly individual ‘mind’ that is in constant dialogue with the environment. Since the 21stCentury, especially over the last year, is transforming our environment in unprecedented ways, it follows that human brains, and thus our minds, could also be undergoing unprecedented changes. Possibilities range from robotic-type attitudes through to infantilized mindsets to perhaps realising an unprecedented individual potential. Insights from neuroscience might help us anticipate what lies ahead and, most importantly, suggest how we might mitigate the risks and maximise opportunities to make the most of the mid-21st Century.