What indispensable solutions helped you modernize your IT infrastructure?

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IT Consultant in Finance (non-banking), Self-employed
Okta was an absolute key to my success modernizing IT.  Centralizing identity and strong authentication finally enabled a Bank to choose the cloud native apps we wanted and begin our transformation in a secure and compliant manner.
CIO - India in Retail, 1,001 - 5,000 employees
Cloud + Microservices.
Senior Director - Enterprise IT & Cloud Transformation in Services (non-Government), 10,001+ employees
Platform approach is the key, eg API, Analytics, , DevSecOps IT4IT..and off-course Hybrid Cloud....with this you are on the journey of Mordenization to achieve Digital journey.
Chief Cloud Officer in Software, Self-employed
I say what Joydeep says and will add containers to run the microservices.
CIO in Healthcare and Biotech, 51 - 200 employees
For us, it started with a vision and commitment to a fundamental transformation (in our case, a cloud first strategy). Once we had that, we started with easy wins like moving from Exchange to Gmail, internal HD to Zendesk). Next we addressed the key business systems like Finance/Payroll, CRM, etc. Finally all residual systems were moved to IaaS and PaaS platforms. The easy wins helped with understanding and buy-in for the bigger projects. Now we are an OpEx focused operation and don't need to spend time on that discussion (or on all the maintenance that bogged down the IT organization previously). Recent additions like Okta (IAM) and Wombat (Security Awareness) have been strong additions. A fundamental key no to overlook is having a strong and flexible integration platform/service, but that's another thread. 
CIO in Software, 51 - 200 employees
I think THE Solution is not a tool, but first to be clear on what you want to achieve with your 'modernization'. I think a very common objective is now a days to gain speed and flexibility to CHANGE. Especially as it's hard to predict the future, you want to be able to quickly adapt without being locked-up. And surely there are a lot of initiatives out like cloud native, DevOps etc. approaches (including the comments which have been made before) which are very much linked to those objectives. Looking at ourselves and our Fortune 500 customers that's for sure the initiative a lot of them are taking. But be careful of the complexity you are adding with microservices, but manageable with the right approaches. For our very own business system I have set a few principles to ensure that we have the right speed and flexibility: 'SaaS only', Buy rather than Make, But Clear Make, when we gain competitive advantage !
Former Chief Technology and People Officer in Software, 1,001 - 5,000 employees
CIO in Education, 1,001 - 5,000 employees
Working on a cloud strategy document so we could fully understand and make better decision on where we need to modernize and why.
CIO in Consumer Goods, 51 - 200 employees
Aside from Cloud, you may want to consider hyper convergence 

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CTO in Software, 201 - 500 employees
Without a doubt - Technical Debt! It's a ball and chain that creates an ever increasing drag on any organization, stifles innovation, and prevents transformation.
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