How do you feel about (and deal with) the scheduling challenges and time zone differences when working with global teams, including early morning and late-night meetings?

It's a balance. Our teams in Bulgaria and India will often join calls late in their evenings and I feel that we (in the US) should be flexible where possible too.

When I led a team of product managers in both India and US (east and west coast) we swapped the weekly cadence for our team call between EST late am and EST late pm to accommodate.

Again it comes back to being flexible and understanding everyone should have a good work/life balance.

I have lots of experience working with global teams.  It is not uncommon to have engineering staff, especially in the endpoint security market, located in remote locations like India and Israel.  What this means for a US based product manager, especially one like me that lives on the west coast is very early morning meetings.  Many times starting the day at 5am.  Being a global company, everyone has to give a little.  Our India teams try to match US hours and work very late into the evening.  The challenge comes when I need a response and have to wait 12-18 hours until those remote sites come online.

Early morning meetings are fine until you have perhaps a customer call with entities in Asia/Pac.  This results in some late evening calls.

In the end, it is a balancing act....  Some days are normal and end mid-afternoon if I have a 5am call, but some become very long if I have to deal with countries in Asia Pac.

I have been doing this a long time and very much used to the schedule.  A new product manager might be overwhelmed with the amount of hours required to service the globe.

I hope that provides some insight. 

Using Wrike has helped to reduce meetings, we have been able to communicate async and move projects forward.