The human brain becomes highly personalized after birth by the development of unique configurations of connections between the brain cells that characterize its subsequent growth, personalizing it into a highly individual ‘mind’ that is in constant dialogue with the environment. The past two years have imposed an unprecedented experiment on the human mind, having effects in ways and to extents that are hard to predict. Insights from neuroscience might help us anticipate what lies ahead and, most importantly, suggest how we might mitigate the risks and maximise opportunities to make the most of recent changes and disruption. Join Baroness Susan Greenfield as she explores how the 21st Century is transforming our environment, and subsequently, the human mind.