As frontier AI models gain agentic capability, the time between vulnerability discovery and exploitation is compressing and exploit chains are becoming easier to assemble at scale. This raises the likelihood of high-velocity attacks that can overwhelm traditional patching, vulnerability triage, and incident response operating rhythms. This session provides an I&O playbook to reduce exposure and contain blast radius through deterministic asset inventory, attack-path prioritization, identity and privilege hardening, segmentation, and automated remediation.